comparison of antiulcer effects of tricyclic antidepressants with cimetidine and omeprazole in rats

the antiulcer effects of different tricyclic antidepressants (trimipramine, doxepin, imipramine, and amitriptyline) in comparison with those of cimetidine, pirenzepine and omeprazole were investigated in male rats with acute gastric ulcer. acute gastric ulcer was induced by oral administration of o. 6n hcl solution, 1 ml/rat. pretreatment of animals with doxepin, trimipramine, amitriptyline, imipramine (in doses of 10, 25, 40, 50, and 75 mg/kg, sc), cimetidine (in doses of 50,75, 100, 150 and 200 mg/kg, sc), omeprazole and pirenzepine (in doses of 10, 20, 30,40 and 50 mg/kg, sc) inhibited the formation of erosions dose-dependently. the ed 50 of these agents revealed that the most active agents were omeprazole, doxepin and pirenzepine, followed by trimipramine and cimetidine. imipramine and amitriptyline had slight antiulcer activity.